Visible changes: 4 to 6 sessions are usually required for lasting effects
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The mechanism: STAT5 phosphorylation peaks within 30 minutes of GH binding, then dephosphorylates over 90120 minutes
Nevertheless, stressful conditions, including exaggerated oxidative stress, inflammation, impaired autophagy and heightened glutamate level, are believed to be linked with abnormal protein misfolding and accumulation of misfolded proteins and calcium, with the resultant enhanced ER stress